Venki Ramakrishnan was awarded the 2009 Nobel Prize in chemistry for “studies of the structure and function of the ribosome” and in 2015 became president of the Royal Society.
We are facing a global health problem with the emergence of antibiotic resistant strains of bacteria. A large number of antibiotics work by preventing bacteria from making proteins, which are essential to carry out the various functions of all life. Proteins are made using instructions encoded in our genes by a large molecular machine called the ribosome. The ribosome is enormous in molecular terms, because it consists of almost half a million atoms. Solving its precise atomic structure was crucial to understand how it worked. It also showed how antibiotics bind to it and how new ones could be designed. The ribosome is also ancient and the structure provides strong evidence that it emerged from a primordial RNA world and by making proteins, helped to transform life into the form we know today.
Join Venki as he talks to Roger Highfield about his ground-breaking research.
The gardening historian and travel writer embarks on extraordinary journeys through Italy, exploring the curious past and present of citrus fruit, uncovering the origins of the Mafia among Sicily’s lemon groves and meeting Orthodox Jewish citron merchants in Calabria.
Just as water is wet in a way that individual water molecules aren’t, big data can reveal information in a way that individual bits of data can’t. The tech and business gurus show us the surprising ways that enormous, complex and messy collections of data can be used to predict everything from shopping patterns to flu outbreaks. Chaired by Stephanie Flanders.
Zambra’s Ways Of Going Home is the tragic story of the collateral damage caused by the Pinochet regime, and the burden borne by the new generation as they come to terms with their fragile history. Magden’s Ali And Ramazan pitches its two friends out of the safety of their orphanage onto the streets of Istanbul with tragic consequences.
The peerless sketch writer yarns 20 Glorious Years In Parliament.
The former BP boss, now chairman of Cuadrilla, launches his frank examination of sexuality and leadership The Glass Closet: Why Coming Out is Good for Business. He talks to Peter Florence.
Meeting the captain, the F-18 pilots and the dentists, experiencing everything from a man-overboard alert to the Steel Beach Party, Dyer guides us through the most AIE (acronym intensive environment) imaginable. Underlying Dyer’s efforts to overcome the disadvantages of being the oldest, tallest (actually, second tallest), and most self-conscious person on the boat is an intense fascination with the military world.
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Two authors discuss how bereavement encouraged them to tell their own life stories against all the odds, in a society where men still often suffer silently. Historian and Professor Hywel Francis chairs Byw Nawr/Live Now, the end-of-life-care coalition in Wales. He talks to ex-miner George Brinley Evans and broadcaster Phil Steele. Taubert is a palliative and end-of-life-care consultant at Velindre Cancer Centre. They offer a clinical perspective on male depression and grief.
Rich in analysis and anecdote, the BBC’s Europe Editor examines the roots and routes of the economic crisis – Europe’s Darkest Hour Since World War Two.
Fierce, astringent, profoundly tender - and spanning the twentieth century, this beautifully orchestrated novel explores the big themes of betrayal and the struggle for happiness, and above all, the passionate love of a childhood friendship as it is tested over a lifetime. Tremain’s award-winning fiction includes Music and Silence, The Road Home, Sacred Country, Restoration and The Colour. She talks to Peter Florence.